TBXAS1
-
Official Full Name
thromboxane A synthase 1 (platelet) -
Overview
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
TBXAS1;thromboxane A synthase 1 (platelet);thromboxane A synthase 1 (platelet, cytochrome P450, subfamily V);thromboxane-A synthase;CYP5;CYP5A1;cytochrome P450;family 5;subfamily A;polypeptide 1;THAS;TS;TXAS;TXS;Cytochrome P450 5A1;FLJ52771;GHOSAL;THAS_HUMAN;Thromboxane A synthase 1 platelet cytochrome P450 subfamily V;TXA synthase;OTTHUMP00000211927;OTTHUMP00000211928;OTTHUMP00000211929;OTTHUMP00000211930;OTTHUMP00000211931;platelet, cytochrome P450, subfamily V;cytochrome P450, family 5, subfamily A, polypeptide 1;thromboxane;BDPLT14
Recombinant Proteins
- Human
- Cynomolgus
- Zebrafish
- Mouse
- Rat
- Macaca fascicularis
- Bovine
- Sus scrofa (Pig)
- Mus musculus
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- E.coli expression system
- HEK293T
- Mamanlian cells
- GST
- His
- Myc&DDK
- His&T7
- Non
- His&Fc&Avi
- Flag
Involved Pathway
TBXAS1 involved in several pathways and played different roles in them. We selected most pathways TBXAS1 participated on our site, such as Arachidonic acid metabolism,Metabolic pathways,Platelet activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TBXAS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Platelet activation | MYLK2,SNAP23,P2RY1,MYLK,MYLK4,ROCK1,PIK3CB,PLA2G4D,GP1BA,FCGR2A |
| Arachidonic acid metabolism | CYP4F3,CYP2C70,PTGS1,PTGES,ALOX5,CYP1A2,PLA2G5,EPHX2,PTGS2B,GGT5A |
| Metabolic pathways | UAP1L1,UROC1,GMPPB,NDUFA7,IDS,OXSR1,SPTLC1,CYP2J5,PPOX,DHRS3B |
Protein Function
TBXAS1 has several biochemical functions, for example, guanyl-nucleotide exchange factor activity,protein binding,thromboxane A2 receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TBXAS1 itself. We selected most functions TBXAS1 had, and list some proteins which have the same functions with TBXAS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | TRA2B,RTP2,IGFLR1,DYNLL2,SLC2A1,LMF2,MPRIP,HP1BP3,FAM133A,ARNTL1A |
| thromboxane A2 receptor activity | TBXA2R |
| guanyl-nucleotide exchange factor activity | ARHGEF18,ITSN2A,VAV3,DENND5B,RIC8,RASGEF1BB,RALGDS,ARHGEF3L,TRIO,ARHGEF4 |
Interacting Protein
TBXAS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TBXAS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TBXAS1.
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References
- Munoz, YC; Gomez, GI; et al. Dehydroepiandrosterone Prevents the Aggregation of Platelets Obtained from Postmenopausal Women with Type 2 Diabetes Mellitus through the Activation of the PKC/eNOS/NO Pathway. HORMONE AND METABOLIC RESEARCH 44:625-631(2012).
- Matsui, Y; Amano, H; et al. Thromboxane A2 receptor signaling facilitates tumor colonization through P-selectin-mediated interaction of tumor cells with platelets and endothelial cells. CANCER SCIENCE 103:700-707(2012).
