Recombinant Mouse Stambp Protein, Myc/DDK-tagged

• Cat.No.: Stambp-6159M
• Product Overview: Purified recombinant protein of mouse full-length STAM binding protein (Stambp), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Involved in the ubiquitin-dependent sorting and trafficking of receptors from endosomes to lysosome. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization. Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways.
• Molecular Mass: 48.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Stambp STAM binding protein [ Mus musculus (house mouse) ]
• Official Symbol: Stambp
• Synonyms: STAMBP; STAM binding protein; STAM-binding protein; associated molecule with the SH3 domain of STAM; Amsh; AW107289; mKIAA4198; 5330424L14Rik; 5730422L11Rik; KIAA4198
• Gene ID: 70527
• mRNA Refseq: NM_024239
• Protein Refseq: NP_077201
• UniProt ID: Q9CQ26