Recombinant Mouse Srpk2 Protein, Myc/DDK-tagged
Cat.No. : | Srpk2-6131M |
Product Overview : | Purified recombinant protein of mouse full-length serine/arginine-rich protein specific kinase 2 (Srpk2), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
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Species : | Mouse |
Source : | HEK293 |
Tag : | DDK&Myc |
Description : | Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation. Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28. Probably by phosphorylating DDX23, leads to the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA. |
Molecular Mass : | 76.9 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name | Srpk2 serine/arginine-rich protein specific kinase 2 [ Mus musculus (house mouse) ] |
Official Symbol | Srpk2 |
Synonyms | SRPK2; serine/arginine-rich protein specific kinase 2; SRSF protein kinase 2; SFRS protein kinase 2; WW domain binding protein 6; SR-protein-specific kinase 2; serine/threonine-protein kinase SRPK2; serine/arginine-rich protein-specific kinase 2; Wbp6; mSRPK2; AW226533; AW492537; AW547358 |
Gene ID | 20817 |
mRNA Refseq | NM_009274 |
Protein Refseq | NP_033300 |
UniProt ID | O54781 |
◆ Recombinant Proteins | ||
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SRPK2-8724M | Recombinant Mouse SRPK2 Protein, His (Fc)-Avi-tagged | +Inquiry |
SRPK2-2663H | Recombinant Human SRPK2 Protein, Myc/DDK-tagged, C13 and N15-labeled | +Inquiry |
SRPK2-1069H | Recombinant Human SRPK2 Protein (S2-N688), Tag Free | +Inquiry |
SRPK2-6659HF | Active Recombinant Full Length Human SRPK2 Protein, GST-tagged | +Inquiry |
◆ Cell & Tissue Lysates | ||
SRPK2-1474HCL | Recombinant Human SRPK2 293 Cell Lysate | +Inquiry |
Not For Human Consumption!
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