Recombinant Human SFRS Protein Kinase 2, GST-tagged, Active

• Cat.No.: SRPK2-436H
• Product Overview: Recombinant full-length human SRPK2 was expressed by baculovirus inSf9insect cells using an N-terminal GST tag. MW = 135 kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Description: SRPK2 is a member of the serine/arginine (SR) protein-specific kinase family that are cell cycle-regulated protein kinases which phosphorylate SR domain-containing proteins in nuclear speckles and mediate the pre-mRNA splicing events. SRPK2 knock down results in hypophosphorylation of the serine/arginine domain-containing human PRP28 protein thereby destabilizing PRP28 association with the tri-snRNP. RNAi-mediated depletion in HeLa cells showed that SRPK2 is essential for cell viability, and it is required for spliceosomal B complex formation.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: SRPK2 SFRS protein kinase 2 [ Homo sapiens ]
• Synonyms: SRPK2; SFRS protein kinase 2; SFRSK2; FLJ36101; serine/arginine-rich protein-specific kinase 2; H_RG152G17.1a; H_RG152G17.1b; WUGSC:H_RG152G17.1a; serine kinase SRPK2; EC 2.7.11.1; SR-protein-specific kinase 2; Serine/threonine-protein kinase SRPK2
• Gene ID: 6733
• mRNA Refseq: NM_182691
• Protein Refseq: NP_872633
• MIM: 602980
• UniProt ID: P78362
• Chromosome Location: 7q22-q31.1
• Function: ATP binding; magnesium ion binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; transferase activity