Recombinant Mouse Sigirr Protein, Myc/DDK-tagged

• Cat.No.: Sigirr-5875M
• Product Overview: Purified recombinant protein of mouse full-length single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (Sigirr), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 46.2 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Sigirr single immunoglobulin and toll-interleukin 1 receptor (TIR) domain [ Mus musculus (house mouse) ]
• Official Symbol: Sigirr
• Synonyms: SIGIRR; single immunoglobulin and toll-interleukin 1 receptor (TIR) domain; single Ig IL-1-related receptor; toll/interleukin-1 receptor 8; single Ig IL-1R-related protein; single Ig IL-1R-related molecule; single Ig IL-1 receptor related protein; single immunoglobulin domain-containing IL1R-related protein; TIR8; AI256711; MGC102426
• Gene ID: 24058
• mRNA Refseq: NM_023059
• Protein Refseq: NP_075546
• UniProt ID: Q9JLZ8