Recombinant Mouse Sh2b3 Protein, MYC/DDK-tagged

• Cat.No.: Sh2b3-1332M
• Product Overview: Purified recombinant protein of full-length mouse SH2B adaptor protein 3 (Sh2b3), with C-terminal MYC/DDK tag, was expressed in HEK293T cells.

Specification

• Description: This gene encodes a member of the SH2B family of adapter proteins that play an important role in T cell receptor signaling. This gene is preferentially expressed in hematopoietic stem cells, hematopoietic progenitors, pre and immature B cells, as well as megakaryocytes and mastocytes. In hematopoietic stem cells, the encoded protein is a key regulator of self-renewal, proliferation and apoptosis. Mice lacking the encoded protein exhibit pre and immature B cell expansion in spleen and the bone marrow. Alternative splicing results in multiple transcript variants encoding different isoforms.
• Molecular Mass: 60.9 kDa
• Purity: >80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 µg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Sh2b3 SH2B adaptor protein 3 [ Mus musculus (house mouse) ]
• Official Symbol: Sh2b3
• Synonyms: Sh2b3; SH2B adaptor protein 3; Lnk; AI429800; SH2B adapter protein 3; linker of T-cell receptor pathways; lymphocyte-specific adapter protein Lnk; signal transduction protein Lnk
• Gene ID: 16923
• mRNA Refseq: NM_008507
• Protein Refseq: NP_032533
• UniProt ID: O09039