SH2B3
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Official Full Name
SH2B adaptor protein 3 -
Overview
This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus. -
Synonyms
SH2B3;SH2B adaptor protein 3;SH2B adapter protein 3;IDDM20;LNK;lymphocyte adaptor protein;signal transduction protein Lnk;lymphocyte-specific adapter protein Lnk
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Mammalian cells
- His
- Non
- Myc&DDK
- His&Flag
- His&T7
- His&Fc&Avi
- Flag
Involved Pathway
SH2B3 involved in several pathways and played different roles in them. We selected most pathways SH2B3 participated on our site, such as EPO signaling pathway,Factors involved in megakaryocyte development and platelet production,Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SH2B3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Factors involved in megakaryocyte development and platelet production | MAFGA,PHF21A,CABLES2,HBBE3,MYB,DOCK1,DOCK6,DOCK2,BA1L,KIFC1 |
| Neurotrophin signaling pathway | RPS6KA6,BAX,PTPN11,NTF4,GSK3B,CALM4,PIK3CB,PIK3R2,CDC42,RELA |
| Signaling events mediated by Stem cell factor receptor (c-Kit) | MAP4K1,STAP1,EVLA,PTPRO |
| Signaling by SCF-KIT | PTPRU,PTPRUB,GRAP |
| Signal Transduction | HECW1,LPAR2A,RAB6A,BCO2L,ARHGAP15,USP34,ADM2A,TULP3,SKILB,ANXA1A |
| Hemostasis | F3A,DGKG,SLC16A8,ABHD6B,ZFPM2A,GATA5,MYB,CD9B,GLG1B,S100A10B |
Protein Function
SH2B3 has several biochemical functions, for example, phosphate ion binding,protein binding,protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SH2B3 itself. We selected most functions SH2B3 had, and list some proteins which have the same functions with SH2B3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| signaling adaptor activity | AFAP1L2,SH2B1,HOMER1,GNB2L1,LDLRAP1,SH2B2,MPP7 |
| protein binding | TXNL4A,C1orf109,KDM5B,XK,SMPD1,SMC4,ALKBH4,REV1,IST1,PINX1 |
| signal transducer activity | OLFR49,TACR3L,TAS2R126,TAS2R113,CBLB,GPR98,TAS2R124,OLFCS2,S100A9,RHOC |
| phosphate ion binding | RELA,ADSSL1,CHST14,RPH3A,SLC34A2,MTHFD2,G6PC,OTC,PNP,GNG12 |
| protein complex binding | KRT8,RAD18,NFYB,PFKP,Apba1,ITGB1BP1,FBLN1,KIF11,CDK5RAP2,ATM |
Interacting Protein
SH2B3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SH2B3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SH2B3.
EGFR;ERBB2;MET;KIT;ERBB3
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References
- Ochoa, E; Iriondo, M; et al. Thrombotic Antiphospholipid Syndrome Shows Strong Haplotypic Association with SH2B3-ATXN2 Locus. PLOS ONE 8:-(2013).
- Bonifacio, E; Krumsiek, J; et al. A strategy to find gene combinations that identify children who progress rapidly to type 1 diabetes after islet autoantibody seroconversion. ACTA DIABETOLOGICA 51:403-411(2014).
