Recombinant Mouse Sh2b2 Protein, Myc/DDK-tagged

• Cat.No.: Sh2b2-5833M
• Product Overview: Purified recombinant protein of mouse full-length SH2B adaptor protein 2 (Sh2b2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3.
• Molecular Mass: 66.6 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Sh2b2 SH2B adaptor protein 2 [ Mus musculus (house mouse) ]
• Official Symbol: Sh2b2
• Synonyms: SH2B2; SH2B adaptor protein 2; SH2B adapter protein 2; insulin receptor substrate 5; SH2 and PH domain-containing adapter protein APS; adapter protein with pleckstrin homology and Src homology 2 domains; adaptor protein with pleckstrin homology and src homology 2 domains; Aps
• Gene ID: 23921
• mRNA Refseq: NM_018825
• Protein Refseq: NP_061295
• UniProt ID: Q9JID9