Recombinant Mouse Serpine1

• Cat.No.: Serpine1-2462M
• Product Overview: Recombinant Mouse Serpine1 was expressed inE.Coli.It was the ideal choice for studies involving this animal model of fibrinolysis and cancer studies. The active fraction typically contained 70 percent active PAI-1. MW=43 KDa.

Specification

• Species: Mouse
• Source: E.coli
• Tag: Non
• Description: Plasminogen activator inhibitor-1 is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), the activators of plasminogen and hence fibrinolysis (the physiological breakdown of blood clots). It is a serine protease inhibitor (serpin) protein (SERPINE1).The other PAI, plasminogen activator inhibitor-2 (PAI-2) is secreted by the placenta and only present in significant amounts during pregnancy. In addition, protease nexin acts as an inhibitor of tPA and urokinase. PAI-1, however, is the main inhibitor of the plasminogen activators.
• Concentration: 2.5 mg/ml.
• Volume: 0.2 ml.
• Buffer: 0.05 M Sodium Acetate; 0.1 M NaCl; 1 mM EDTA; pH 5.0.
• Form: Frozen liquid.
• Shipping Information: Recommended Storage: -70℃; Shipping Conditions: Dry ice; Minimum Shelf Life: 3 years from delivery.

Gene Information

• Gene Name: Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 [ Mus musculus ]
• Synonyms: Serpine1; serine (or cysteine) peptidase inhibitor, clade E, member 1; PAI1; PAI-1; Planh1; plasminogen activator inhibitor 1; PAI; serpin E1; plasminogen activator inhibitor, type I; endothelial plasminogen activator inhibitor; nexin, plasminogen activator inhibitor type 1; serine (or cysteine) proteinase inhibitor, clade E, member 1; Plasminogen activator inhibitor-1 precursor (PAI-1) (Endothelial plasminogen activator inhibitor) (PAI)
• Gene ID: 18787
• mRNA Refseq: NM_008871
• Protein Refseq: NP_032897
• UniProt ID: P22777
• Chromosome Location: 5 G2
• Pathway: Chagas disease; Complement and coagulation cascades; p53 signaling pathway
• Function: peptidase inhibitor activity; protein binding; serine-type endopeptidase activity; serine-type endopeptidase inhibitor activity