Recombinant Mouse Serpina3n Protein, His-tagged

• Cat.No.: Serpina3n-530M
• Product Overview: Recombinant Mouse Serpina3n Protein(NP_033278.2) (Phe21-Lys418), fused to a 6His tag at the C-terminuss, was expressed in Mammalian expression system.

Specification

• Description: Serine protease inhibitor A3N(Serpin A3N) is a serine protease inhibitor that is structurally related to α1 antichymotrypsin encoded by the SERPINA3 gene. Serpin A3N is highly expressed in brain, testis, lung, thymus, and spleen. It is expressed with low levels in bone marrow, kidney and skeletal muscle. Serpin A3N secreted by Sertoli cells may regulate the activity of locally produced Granzyme B. Granzyme B inhibition by Serpin A3N may therefore regulate Granzyme Bmediated killing by cytotoxic lymphocytes, providing a means to disable cellmediated immune responses.
• Source: HEK293
• Species: Mouse
• Tag: His
• Form: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH8.0.
• Molecular Mass: 58kDa, reducing conditions.
• Protein length: Phe21-Lys418
• Endotoxin: Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
• Purity: Greater than 95% as determined by reducing SDS-PAGE
• Storage: Store at ≤-70°C, stable for 6 months after receipt.
  Store at ≤-70°C, stable for 3 months under sterile conditions after opening.
  Please minimize freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.25 mg/ml. Centrifuge the vial at 4°C before opening to recover the entire contents.
• Shipping: The product is shipped on dry ice/polar packs.
  Upon receipt, store it immediately at the temperature listed below.

Gene Information

• Gene Name: Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N [ Mus musculus (house mouse) ]
• Official Symbol: Serpina3n
• Synonyms: Spi; ant; Spi2-2; Spi2.2; Spi2/e; Spi2/eb.4
• Gene ID: 20716
• mRNA Refseq: NM_009252.2
• Protein Refseq: NP_033278.2
• UniProt ID: Q91WP6