Recombinant Mouse Sdcbp Protein, Myc/DDK-tagged

• Cat.No.: Sdcbp-5728M
• Product Overview: Purified recombinant protein of mouse full-length syndecan binding protein (Sdcbp), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis. Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1. In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis. Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 32.4 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Sdcbp syndecan binding protein [ Mus musculus (house mouse) ]
• Official Symbol: Sdcbp
• Synonyms: SDCBP; syndecan binding protein; syntenin-1; syntenin; scaffold protein Pbp1; syndecan-binding protein 1; syndecan interacting protein; Sycl; MDA-9
• Gene ID: 53378
• mRNA Refseq: NM_001098227
• Protein Refseq: NP_001091697
• UniProt ID: O08992