Recombinant Mouse Rraga Protein, Myc/DDK-tagged

• Cat.No.: Rraga-5619M
• Product Overview: Purified recombinant protein of mouse full-length Ras-related GTP binding A (Rraga), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death.
• Molecular Mass: 36.6 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Rraga Ras-related GTP binding A [ Mus musculus (house mouse) ]
• Official Symbol: Rraga
• Synonyms: Rraga; Ras-related GTP binding A; FIP; RAGA; FIP-1; AI255374; 1300010C19Rik; ras-related GTP-binding protein A; rag A
• Gene ID: 68441
• mRNA Refseq: NM_178376
• Protein Refseq: NP_848463
• UniProt ID: Q80X95