Recombinant Mouse Rbl2 Protein, Myc/DDK-tagged

• Cat.No.: Rbl2-5409M
• Product Overview: Purified recombinant protein of mouse full-length RB transcriptional corepressor like 2 (Rbl2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 127.9 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Rbl2 RB transcriptional corepressor like 2 [ Mus musculus (house mouse) ]
• Official Symbol: Rbl2
• Synonyms: RBL2; retinoblastoma-like 2; retinoblastoma-like protein 2; PRB2; RBR-2; retinoblastoma-related protein 2; 130 kDa retinoblastoma-associated protein; Rb2; p130
• Gene ID: 19651
• mRNA Refseq: NM_011250
• Protein Refseq: NP_035380
• UniProt ID: Q64700