Recombinant Mouse Ranbp9 Protein, Myc/DDK-tagged

• Cat.No.: Ranbp9-5369M
• Product Overview: Purified recombinant protein of mouse full-length RAN binding protein 9 (Ranbp9), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways. Acts as a mediator of cell spreading and actin cytoskeleton rearrangement. Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 76.2 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Ranbp9 RAN binding protein 9 [ Mus musculus (house mouse) ]
• Official Symbol: Ranbp9
• Synonyms: RANBP9; RAN binding protein 9; ran-binding protein 9; ran-binding protein M; B cell antigen receptor Ig beta associated protein 1; B-cell antigen receptor Ig beta-associated protein 1; Ibap1; IBAP-1; RanBPM
• Gene ID: 56705
• mRNA Refseq: NM_019930
• Protein Refseq: NP_064314
• UniProt ID: P69566