Recombinant Mouse Ranbp3 Protein, Myc/DDK-tagged

• Cat.No.: Ranbp3-5367M
• Product Overview: Purified recombinant protein of mouse full-length RAN binding protein 3 (Ranbp3), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export.
• Molecular Mass: 52.6 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Ranbp3 RAN binding protein 3 [ Mus musculus (house mouse) ]
• Official Symbol: Ranbp3
• Synonyms: RANBP3; RAN binding protein 3; ran-binding protein 3; AA408221; 2610024N24Rik
• Gene ID: 71810
• mRNA Refseq: NM_027933
• Protein Refseq: NP_082209
• UniProt ID: Q9CT10