Recombinant Mouse Rabgap1l Protein, Myc/DDK-tagged

• Cat.No.: Rabgap1l-5338M
• Product Overview: Purified recombinant protein of mouse full-length RAB GTPase activating protein 1-like (Rabgap1l), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP. Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration.
• Molecular Mass: 43.2 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Rabgap1l RAB GTPase activating protein 1-like [ Mus musculus (house mouse) ]
• Official Symbol: Rabgap1l
• Synonyms: RABGAP1L; RAB GTPase activating protein 1-like; rab GTPase-activating protein 1-like; rab6 GTPase activating protein-like; HHL; Hh1; AW049894; mKIAA0471; 5830411O09Rik; 8430421H08Rik; 9630005B12Rik
• Gene ID: 29809
• mRNA Refseq: NM_001038621
• Protein Refseq: NP_001033710
• UniProt ID: A6H6A9