Recombinant Mouse Rab21 Protein, Myc/DDK-tagged

• Cat.No.: Rab21-5297M
• Product Overview: Purified recombinant protein of mouse full-length RAB21, member RAS oncogene family (Rab21), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: Myc&DDK
• Description: Small GTPase involved in membrane trafficking control. Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general. As a result, may regulate cell adhesion and migration. During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis. Involved in neurite growth. Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion. Modulates protein levels of the cargo receptors TMED2 and TMED10, and required for appropriate Golgi localization of TMED10.
• Molecular Mass: 24.6 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Rab21 RAB21, member RAS oncogene family [ Mus musculus (house mouse) ]
• Official Symbol: Rab21
• Synonyms: Rab21; RAB21, member RAS oncogene family; 9630024B22; ras-related protein Rab-21; rab-12; EC 3.6.5.2
• Gene ID: 216344
• mRNA Refseq: NM_024454
• Protein Refseq: NP_077774
• UniProt ID: P35282