Recombinant Mouse Rab11b Protein, Myc/DDK-tagged

• Cat.No.: Rab11b-5284M
• Product Overview: Purified recombinant protein of mouse full-length RAB11B, member RAS oncogene family (Rab11b), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: Myc&DDK
• Description: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11B plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis.
• Molecular Mass: 24.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Rab11b RAB11B, member RAS oncogene family [ Mus musculus (house mouse) ]
• Official Symbol: Rab11b
• Synonyms: RAB11B; RAB11B, member RAS oncogene family; ras-related protein Rab-11B; A730055L17Rik
• Gene ID: 19326
• mRNA Refseq: NM_008997
• Protein Refseq: NP_033023
• UniProt ID: P46638