Recombinant Mouse Plekho1 Protein, Myc/DDK-tagged

• Cat.No.: Plekho1-4934M
• Product Overview: Purified recombinant protein of mouse full-length pleckstrin homology domain containing, family O member 1 (Plekho1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: Myc&DDK
• Description: Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.
• Molecular Mass: 46 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Plekho1 pleckstrin homology domain containing, family O member 1 [ Mus musculus (house mouse) ]
• Official Symbol: Plekho1
• Synonyms: PLEKHO1; pleckstrin homology domain containing, family O member 1; pleckstrin homology domain-containing family O member 1; Jun zipper-associated 2; CK2 interacting protein 1; PH domain-containing family O member 1; TNF intracellular domain-interacting protein; Jza2; Ckip1; JZA-20; 2810052M02Rik; MGC151380
• Gene ID: 67220
• mRNA Refseq: NM_023320
• Protein Refseq: NP_075809
• UniProt ID: Q9JIY0