Recombinant Mouse Pip4k2a Protein, Myc/DDK-tagged

• Cat.No.: Pip4k2a-4873M
• Product Overview: Purified recombinant protein of mouse full-length phosphatidylinositol-5-phosphate 4-kinase, type II, alpha (Pip4k2a), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Has both ATP- and GTP-dependent kinase activities. May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size May negatively regulate insulin-stimulated glucose uptake by lowering the levels of PtdIns5P.
• Molecular Mass: 46.2 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Pip4k2a phosphatidylinositol-5-phosphate 4-kinase, type II, alpha [ Mus musculus (house mouse) ]
• Official Symbol: Pip4k2a
• Synonyms: PIP4K2A; phosphatidylinositol-5-phosphate 4-kinase, type II, alpha; phosphatidylinositol-5-phosphate 4-kinase type-2 alpha; PIP4KII-alpha; PI(5)P 4-kinase type II alpha; diphosphoinositide kinase 2-alpha; ptdIns(5)P-4-kinase isoform 2-alpha; 1-phosphatidylinositol-5-phosphate 4-kinase 2-alpha; phosphatidylinositol-4-phosphate 5-kinase, type II, alpha; Pip5k2a; AW742916
• Gene ID: 18718
• mRNA Refseq: NM_008845
• Protein Refseq: NP_032871
• UniProt ID: O70172