PIP4K2A
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Official Full Name
phosphatidylinositol-5-phosphate 4-kinase, type II, alpha -
Overview
Phosphatidylinositol-5,4-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. The protein encoded by this gene is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. The amino acid sequence of this enzyme does not show homology to other kinases, but the recombinant protein does exhibit kinase activity. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. -
Synonyms
PIP4K2A;phosphatidylinositol-5-phosphate 4-kinase, type II, alpha;phosphatidylinositol 4 phosphate 5 kinase, type II, alpha , PIP5K2A;phosphatidylinositol-5-phosphate 4-kinase type-2 alpha;PIP5KIIA;PIP5KIIalpha;PIP5KIII;PIP4KII-alpha;PI(5)P 4-kina
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- E.coli
- Sf9 Insect Cell
- Insect Cell
- Insect (sf21)
- Mammalian Cell
- HEK293
- HEK293T
- Mammalian cells
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
- Flag
Involved Pathway
PIP4K2A involved in several pathways and played different roles in them. We selected most pathways PIP4K2A participated on our site, such as Inositol phosphate metabolism,Phosphatidylinositol signaling system,Regulation of actin cytoskeleton, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIP4K2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phosphatidylinositol signaling system | PIP5K1B,CALM1,TMEM55A,ITPKB,PI4KA,MTMR4,PPIP5K2,PPIP5K1,IP6K1,IMPA2 |
| Regulation of Actin Cytoskeleton | ACTB2,ITGB5,BRAF,FGFR3,SCIN,PPP1R12B,MOS,RAC3,FGF10,FGFR1A |
| Inositol phosphate metabolism | MTMR7B,MTMR1B,PIP5K1AA,IMPA1,IMPAD1,ITPKA,MTMR6,ITPK1,IPMK,PIK3CB |
Protein Function
PIP4K2A has several biochemical functions, for example, 1-phosphatidylinositol-4-phosphate 5-kinase activity,1-phosphatidylinositol-5-phosphate 4-kinase activity,ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIP4K2A itself. We selected most functions PIP4K2A had, and list some proteins which have the same functions with PIP4K2A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 1-phosphatidylinositol-4-phosphate 5-kinase activity | PIP5K1B,PIP5KL1,PIP5K1A,PIP4K2C,PIP5K1C,PIKFYVE,PIP4K2B |
| ATP binding | RFC5,MAPK3,ACSM2,ATP2B1B,STK26,MCCC1,STK35L,DCLK2,CAMK1DB,ABCG2D |
| 1-phosphatidylinositol-5-phosphate 4-kinase activity | PIP4K2C,PIP5K2 |
Interacting Protein
PIP4K2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIP4K2A here. Most of them are supplied by our site. Hope this information will be useful for your research of PIP4K2A.
RAC1;env;GSTK1;ssrna_ug;CSNK2A2;Pip4k2c;EPB41L3
Resources
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References
- Rajala, RVS; Rajala, A; et al. Phosphoinositides: Minor Lipids Make a Major Impact on Photoreceptor Cell Functions. SCIENTIFIC REPORTS 4:-(2014).
- Clarke, JH; Emson, PC; et al. Distribution and Neuronal Expression of Phosphatidylinositol Phosphate Kinase II gamma in the Mouse Brain. JOURNAL OF COMPARATIVE NEUROLOGY 517:296-312(2009).
