Recombinant Mouse Nmnat2 Protein, Myc/DDK-tagged
Cat.No. : | Nmnat2-4444M |
Product Overview : | Purified recombinant protein of mouse full-length nicotinamide nucleotide adenylyltransferase 2 (Nmnat2), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
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Description : | Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor. Catalyzes the formation of NAD+ from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD+. For the pyrophosphorolytic activity prefers NAD+, NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphorylated dinucleotides NADP+, NADPH and NaADP+. Axon survival factor required for the maintenance of healthy axons: acts by delaying Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc&DDK |
Molecular Mass : | 35 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name | Nmnat2 nicotinamide nucleotide adenylyltransferase 2 [ Mus musculus (house mouse) ] |
Official Symbol | Nmnat2 |
Synonyms | NMNAT2; nicotinamide nucleotide adenylyltransferase 2; nicotinamide mononucleotide adenylyltransferase 2; NMN adenylyltransferase 2; naMN adenylyltransferase 1; pyridine nucleotide adenylyltransferase 2; nicotinate-nucleotide adenylyltransferase 1; PNAT1; PNAT2; AI843915; D030041I09Rik; MGC113818 |
Gene ID | 226518 |
mRNA Refseq | NM_175460 |
Protein Refseq | NP_780669 |
UniProt ID | Q8BNJ3 |
Not For Human Consumption!
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