Recombinant Mouse Nmnat2 Protein, Myc/DDK-tagged

Cat.No. : Nmnat2-4444M
Product Overview : Purified recombinant protein of mouse full-length nicotinamide nucleotide adenylyltransferase 2 (Nmnat2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Description : Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor. Catalyzes the formation of NAD+ from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD+. For the pyrophosphorolytic activity prefers NAD+, NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphorylated dinucleotides NADP+, NADPH and NaADP+. Axon survival factor required for the maintenance of healthy axons: acts by delaying Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons.
Source : HEK293T
Species : Mouse
Tag : Myc&DDK
Molecular Mass : 35 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name Nmnat2 nicotinamide nucleotide adenylyltransferase 2 [ Mus musculus (house mouse) ]
Official Symbol Nmnat2
Synonyms NMNAT2; nicotinamide nucleotide adenylyltransferase 2; nicotinamide mononucleotide adenylyltransferase 2; NMN adenylyltransferase 2; naMN adenylyltransferase 1; pyridine nucleotide adenylyltransferase 2; nicotinate-nucleotide adenylyltransferase 1; PNAT1; PNAT2; AI843915; D030041I09Rik; MGC113818
Gene ID 226518
mRNA Refseq NM_175460
Protein Refseq NP_780669
UniProt ID Q8BNJ3

Not For Human Consumption!

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