Recombinant Mouse Neurod2 Protein, Myc/DDK-tagged

• Cat.No.: Neurod2-4384M
• Product Overview: Purified recombinant protein of mouse full-length neurogenic differentiation 2 (Neurod2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates with chromatin to the DPYSL3 E box-containing promoter.
• Molecular Mass: 41.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Neurod2 neurogenic differentiation 2 [ Mus musculus (house mouse) ]
• Official Symbol: Neurod2
• Synonyms: NEUROD2; neurogenic differentiation 2; neurogenic differentiation factor 2; neuroD-related factor; Ndrf; bHLHa1
• Gene ID: 18013
• mRNA Refseq: NM_010895
• Protein Refseq: NP_035025
• UniProt ID: Q62414