Recombinant Mouse Ndel1 Protein, Myc/DDK-tagged

• Cat.No.: Ndel1-4321M
• Product Overview: Purified recombinant protein of mouse full-length nuclear distribution gene E-like homolog 1 (A, with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts.
• Molecular Mass: 35.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Ndel1 nudE neurodevelopment protein 1 like 1 [ Mus musculus (house mouse) ]
• Official Symbol: Ndel1
• Synonyms: Ndel1; nudE neurodevelopment protein 1 like 1; mNud; NUDEL; MITAP1; mNudel; mNudE-L; 2600006O07Rik; nuclear distribution protein nudE-like 1; nuclear disribution gene E like; nuclear distribution gene E-like homolog 1; protein Nudel
• Gene ID: 83431
• mRNA Refseq: NM_023668
• Protein Refseq: NP_076157
• UniProt ID: Q9ERR1