NDEL1

  • Official Full Name

    nudE nuclear distribution E homolog (A. nidulans)-like 1

  • Overview

    This gene encodes a thiol-activated peptidase that is phosphorylated in M phase of the cell cycle. Phosphorylation regulates the cell cycle-dependent distribution of this protein, with a fraction of the protein bound strongly to centrosomes in interphase and localized to mitotic spindles in early M phase. Overall, this protein plays a role in nervous system development. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

  • Synonyms

    NDEL1;nudE nuclear distribution E homolog (A. nidulans)-like 1;nudE nuclear distribution gene E homolog (A. nidulans) like 1;nuclear distribution protein nudE-like 1;MITAP1;NUDEL;protein Nudel;endooligopeptidase A;mitosin-associated protein 1;mit

Recombinant Proteins

  • Mouse
  • Chicken
  • Rat
  • Human
  • Mammalian Cell
  • HEK293
  • E.coli
  • HEK293T
  • His
  • Non
  • GST
  • His&Fc&Avi
  • Myc&DDK

    Involved Pathway

    NDEL1 involved in several pathways and played different roles in them. We selected most pathways NDEL1 participated on our site, such as Aurora A signaling,Cell Cycle,Cell Cycle, Mitotic, which may be useful for your reference. Also, other proteins which involved in the same pathway with NDEL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Mitotic Anaphase MIS12,CDCA8,NDEL1A,ZWINT,NUF2,NDC80,VRK1,CENPO,SPDL1,LEMD3
    Aurora A signaling AURKAIP1,TDRD7,TPX2,OAZ1,GADD45A,TACC1,CENPA,TACC3,AURKB
    Mitotic Prometaphase SKA1,MIS12,CENPK,SPDL1,AHCTF1,NCAPD2,NUF2,SPC25,DSN1,NCAPH
    Cell cycle SMC1B,CENPO,ORC6,MCM10,TCTN2,ZBTB17,CSNK1D,CCND2,USO1,ARF1
    Cell Cycle, Mitotic NCAPD2,MYCA,NIPBL,DYNC1H1,HAUS2,SETB,CENPL,GINS2,PLK4,SMC4
    Mitotic Metaphase and Anaphase NDEL1A,MIS12,SGOL2,TMPO,PANE1,NUF2,CENPO,RANGAP1B,PDS5B,B9D2
    Lissencephaly gene (LIS1) in neuronal migration and development NUDC,KATNA1,DYNLT1,MAP1B,DAB1,VLDLR,DCX,LRPAP1
    M Phase APITD1,NEK9,DULLARD,GORASP1,MLF1IP,CENPI,CENPA,CDCA5,VRK1,CDCA8

    Protein Function

    NDEL1 has several biochemical functions, for example, alpha-tubulin binding,beta-tubulin binding,microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NDEL1 itself. We selected most functions NDEL1 had, and list some proteins which have the same functions with NDEL1. You can find most of the proteins on our site.

    Function Related Protein
    microtubule binding BCL2L11,KIF18B,CASC1,HOOK3,KIF1C,NDEL1A,CLIP1,SPAG8,KIF4A,CEP57
    protein binding GUCY1A3,CHN2,CTPS2,RNF165,PDLIM2,AKAP8L,LLGL1,LTC4S,WTIP,EBF1
    beta-tubulin binding PACRG,B4GALT1,SNCA,EMD,HTT,CASC1,UXT,RGS2,AKAP1,RANBP10
    alpha-tubulin binding SPAST,CAV3,TRPV4,SNCA,BBS4,INO80,C9orf24,ARL4C,FAM110C,NCALD

    Interacting Protein

    NDEL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NDEL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NDEL1.

    CENPF;DISC1;TRIM27

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