Recombinant Mouse MUSK Protein, His-SUMO/MYC-tagged

• Cat.No.: MUSK-1288M
• Product Overview: Recombinant Mouse MUSK Protein (22-494aa) was expressed in E. coli with N-terminal His-SUMO tag and C-terminal MYC tag.

Specification

• Description: This gene encodes a member of the protein tyrosine kinase family. The encoded protein is a type 1 receptor-like protein located in muscle membrane that is activated by the heparan sulfate proteoglycan agrin released by nerve cells. The encoded protein activates signaling cascades responsible for multiple aspects of motor neuron and muscle development, including organization of the postsynaptic membrane, synaptic gene transcription, patterning of skeletal muscle, anchoring of acetylcholinesterase, and guidance of motor axons. Alternatively spliced transcript variants encoding different isoforms have been described.
• Source: E. coli
• Species: Mouse
• Tag: His&Myc&SUMO
• Form: Tris-based buffer, 50% glycerol.
• Molecular Mass: 69.3 kDa
• AA Sequence: EKLPKAPVITTPLETVDALVEEVATFMCAVESYPQPEISWTRNKILIKLFDTRYSIRENGQLLTILSVEDSDDGIYCCIANNGVGGAVESCGALQVKMKPKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDNALRENSRIAVLESGSLRIHNVQKEDAGQYRCVAKNSLGTAYSKLVKLEVEVFARILRAPESHNVTFGSFVTLRCTAIGIPVPTISWIENGNAVSSGSIQESVKDRVIDSRLQLFITKPGLYTCIATNKHGEKFSTAKAAATVSIAEWSKSQKDSQGYCAQYRGEVCDAVLAKDALVFFNTSYRDPEDAQELLIHTAWNELKAVSPLCRPAAEALLCNHLFQECSPGVVPTPMPICREYCLAVKELFCAKEWQAMEGKAHRGLYRSGMHLLPVPECSKLPSMHRDPTACTRLPYLDYKKENITTFPSITS
• Purity: Greater than 90% as determined by SDS-PAGE.
• Storage: The shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Protein length: 22-494 a.a.

Gene Information

• Gene Name: Musk muscle, skeletal, receptor tyrosine kinase [ Mus musculus (house mouse) ]
• Official Symbol: Musk
• Synonyms: Mlk; Mdk4; Nsk1; Nsk2; Nsk3
• Gene ID: 18198
• mRNA Refseq: NM_001037127.2
• Protein Refseq: NP_001032204.2
• UniProt ID: Q61006