Recombinant Mouse Mtdh Protein, Myc/DDK-tagged

• Cat.No.: Mtdh-4205M
• Product Overview: Purified recombinant protein of mouse full-length metadherin (Mtdh), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: Myc&DDK
• Description: Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.
• Molecular Mass: 63.8 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Mtdh metadherin [ Mus musculus (house mouse) ]
• Official Symbol: Mtdh
• Synonyms: MTDH; metadherin; protein LYRIC; metastasis adhesion protein; lysine-rich CEACAM1 co-isolated protein; 3D3; AEG-1; Lyric; AV353288; 3D3/Lyric; D8Bwg1112e; 2610103J23Rik
• Gene ID: 67154
• mRNA Refseq: NM_026002
• Protein Refseq: NP_080278
• UniProt ID: Q80WJ7