MTDH
-
Official Full Name
metadherin -
Overview
Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. -
Synonyms
MTDH;metadherin;3D3;AEG1;AEG-1;LYRIC;LYRIC/3D3;protein LYRIC;3D3/LYRIC;metastasis adhesion protein;astrocyte elevated gene-1 protein;lysine-rich CEACAM1 co-isolated protein
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- Davidiella tassiana
- Insect Cells
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His&GST
- His
- Myc&DDK
- Non
- His&Fc&Avi
- GST
- Flag
Involved Pathway
MTDH involved in several pathways and played different roles in them. We selected most pathways MTDH participated on our site, such as Gastric cancer network 2,Validated targets of C-MYC transcriptional activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with MTDH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Gastric cancer network 2 | LBR,SNURF,TOP2A,CHTF8,RNF144B,S100A6,CHTF18,CEBPZ,ATAD2,SNRPN |
| Validated targets of C-MYC transcriptional activation | PEG10,CDCA7,DDX18,LIN28B,PRDX3,MINA,MYCT1,IREB2,HUWE1,PDCD10 |
Protein Function
MTDH has several biochemical functions, for example, NF-kappaB binding,RNA polymerase II transcription factor binding,double-stranded RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MTDH itself. We selected most functions MTDH had, and list some proteins which have the same functions with MTDH. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription coactivator activity | TFAP2A,LPIN1,YY1,PIAS1,ARID1A,HSF2,GMEB2,SCAND1,VGLL2,UTF1 |
| poly(A) RNA binding | RPL13,SARS2,RBMX,UBE2O,S100A4,PES1,IFI16,PURG,HNRNPA0,RPL23A |
| RNA polymerase II transcription factor binding | PITX2,ATF4,SPOP,GATA1A,GSC,GATA5,KDM1A,GATA4,TBX3,ID4 |
| double-stranded RNA binding | DROSHA,DDX58,EIF4A1,STAU2,LRRFIP1,RFTN1,MYH4,DGCR8,DHX15,OASL |
| protein binding | KLC1,CIT,DHX8,NKX2,SOX-2,PAK6,SCG2,Apba1,HIST1H4G,AP1M1 |
| NF-kappaB binding | HDAC2,RNF25,COMMD7,NPM1,HIF1AN,RPS3,NFKBID,PSMA6,CDK5RAP3,ANKRD42 |
Interacting Protein
MTDH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MTDH here. Most of them are supplied by our site. Hope this information will be useful for your research of MTDH.
SND1;AGO2;CSNK2A1;EIF1B;RELA;OTUD6B;CREBBP;LYAR;ssrna_ug
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