Recombinant Mouse Mob1b Protein, Myc/DDK-tagged

• Cat.No.: Mob1b-4105M
• Product Overview: Purified recombinant protein of mouse full-length MOB kinase activator 1B (Mob1b), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.
• Molecular Mass: 25.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Mob1b MOB kinase activator 1B [ Mus musculus (house mouse) ]
• Official Symbol: Mob1b
• Synonyms: MOB1B; MOB kinase activator 1B; mob1 homolog 1A; mps one binder kinase activator-like 1A; MOB1, Mps One Binder kinase activator-like 1A; Mobkl1a; AU015450; B230364F10; 1110003E08Rik; MGC129510; MGC129511
• Gene ID: 68473
• mRNA Refseq: NM_026735
• Protein Refseq: NP_081011
• UniProt ID: Q8BPB0