Recombinant Mouse Mob1a Protein, Myc/DDK-tagged

• Cat.No.: Mob1a-4104M
• Product Overview: Purified recombinant protein of mouse full-length MOB kinase activator 1A (Mob1a), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38.
• Molecular Mass: 25.1 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Mob1a MOB kinase activator 1A [ Mus musculus (house mouse) ]
• Official Symbol: Mob1a
• Synonyms: MOB1A; MOB kinase activator 1A; mob1 homolog 1B; mps one binder kinase activator-like 1B; MOB1, Mps One Binder kinase activator-like 1B; MOB1; MOB4B; Mobk1b; Mobkl1b; MGC6884; 4022402H07Rik
• Gene ID: 232157
• mRNA Refseq: NM_145571
• Protein Refseq: NP_663546
• UniProt ID: Q921Y0