Recombinant Human MERTK
Cat.No. : | MERTK-30094TH |
Product Overview : | Recombinant fragment, corresponding to amino acids 578-872 of Human MERTK, expressed by baculovirus in Sf9 insect cells using an N-terminal tag, 58kDa. |
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Species : | Human |
Tag : | Non |
Protein Length : | 578-872 a.a. |
Description : | This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). |
Tissue specificity : | Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines. |
Biological activity : | The Specific activity of MERTK-30094TH was determined to be 1231 nmol/min/mg. |
Form : | Liquid |
Storage buffer : | Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5 |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequence Similarities : | Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.Contains 2 fibronectin type-III domains.Contains 2 Ig-like C2-type (immunoglobulin-like) domains.Contains 1 protein kinase domain. |
Gene Name | MERTK c-mer proto-oncogene tyrosine kinase [ Homo sapiens ] |
Official Symbol | MERTK |
Synonyms | MERTK; c-mer proto-oncogene tyrosine kinase; tyrosine-protein kinase Mer; mer; RP38; |
Gene ID | 10461 |
mRNA Refseq | NM_006343 |
Protein Refseq | NP_006334 |
MIM | 604705 |
Uniprot ID | Q12866 |
Chromosome Location | 2q14.1 |
Pathway | Cell surface interactions at the vascular wall, organism-specific biosystem; Hemostasis, organism-specific biosystem; |
Function | ATP binding; nucleotide binding; receptor activity; transmembrane receptor protein tyrosine kinase activity; |
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◆ Cell & Tissue Lysates | ||
MERTK-413MCL | Recombinant Mouse MERTK cell lysate | +Inquiry |
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MERTK-484HCL | Recombinant Human MERTK cell lysate | +Inquiry |
MERTK-1816MCL | Recombinant Mouse MERTK cell lysate | +Inquiry |
MERTK-001HCL | Recombinant Human MERTK cell lysate | +Inquiry |
Not For Human Consumption!
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