Recombinant Mouse Mb21d1 protein, His & T7-tagged

• Cat.No.: Mb21d1-1625M
• Product Overview: Recombinant Mouse Mb21d1 aa. (Glu211~Lys395 (Accession # Q8C6L5)) fused with N-terminal His & T7 tag was produced in E. coli cells.

Specification

• Species: Mouse
• Source: E.coli
• Tag: His&T7
• Protein Length: Glu211~Lys395
• Description: The protein encoded by this gene is a DNA binding cytosolic protein that catalyzes the synthesis of cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) after sensing the presence of DNA in the cytoplasm. cGAMP binds another protein, Stimulator of interferon genes (STING), leading to the induction of interferons, and a host immune response. Reduced expression of this gene inhibits interferon induction in the presence of some viral infections. Alternative splicing results in multiple transcript variants.
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 24.9kDa
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Purity: >95%
• Applications: SDS-PAGE; WB; ELISA; IP.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage buffer: Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.
• Isoelectric Point: 9.4

Gene Information

• Gene Name: Mb21d1 Mab-21 domain containing 1 [ Mus musculus (house mouse) ]
• Official Symbol: Mb21d1
• Synonyms: Mb21d1; Mab-21 domain containing 1; cGAS; E330016A19Rik; cyclic GMP-AMP synthase; 2'3'-cGAMP synthase; cGAMP synthase; mab-21 domain-containing protein 1
• Gene ID: 214763
• mRNA Refseq: NM_173386.5
• Protein Refseq: NP_775562.2
• UniProt ID: Q8C6L5