Recombinant Mouse Mavs Protein, Myc/DDK-tagged

• Cat.No.: Mavs-3974M
• Product Overview: Purified recombinant protein of mouse full-length mitochondrial antiviral signaling protein (Mavs), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Required for innate immune defense against viruses Acts downstream of DHX33, DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5) Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis.
• Molecular Mass: 53.4 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Mavs mitochondrial antiviral signaling protein [ Mus musculus (house mouse) ]
• Official Symbol: Mavs
• Synonyms: MAVS; mitochondrial antiviral signaling protein; mitochondrial antiviral-signaling protein; IFN-beta promoter stimulator-1; virus-induced signaling adapter; CARD adapter inducing interferon beta; mitochondrial anti-viral signaling protein; interferon beta promoter stimulator protein 1; Visa; IPS-1; cardif; D430028G21Rik; MGC25836
• Gene ID: 228607
• mRNA Refseq: NM_144888
• Protein Refseq: NP_659137
• UniProt ID: Q8VCF0