MAVS
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Official Full Name
mitochondrial antiviral signaling protein -
Overview
This gene encodes an intermediary protein necessary in the virus-triggered beta interferon signaling pathways. It is required for activation of transcription factors which regulate expression of beta interferon and contributes to antiviral immunity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] -
Synonyms
MAVS;mitochondrial antiviral signaling protein;IPS1;VISA;IPS-1;CARDIF;mitochondrial antiviral-signaling protein;IFN-B promoter stimulator 1;CARD adaptor inducing IFN-beta;virus-induced signaling adaptor;virus-induced-signaling adapter;CARD adapter inducing interferon beta;putative NF-kappa-B-activating protein 031N;interferon beta promoter stimulator protein 1
Recombinant Proteins
- Human
- Chicken
- Rhesus macaque
- Rat
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- His
- Non
- His&Fc&Avi
- Flag
- His&GST
- Myc&DDK
- MBP&His&Avi
- N-His-GST
- N-His-SUMO
Involved Pathway
MAVS involved in several pathways and played different roles in them. We selected most pathways MAVS participated on our site, such as RIG-I-like receptor signaling pathway,Cytosolic DNA-sensing pathway,Hepatitis C, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAVS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Influenza A | NFKBIB,EIF2AK3,XPO1,IFNA2,HLA-DRB3,TNFRSF10D,TNFRSF1A,IFNAR2,IL1B,NXF1 |
| Hepatitis C | MAPK1,OCLN,CLDN5,CLDN22,TLR3,PPP2R1A,SOCS3,CLDN1,TNFRSF1A,EIF2AK3 |
| Herpes simplex infection | CYCSB,TAF4B,SRSF2B,BMA1,SRSF6A,IKBKB,CUL1A,H2-AB1,TBPL1,CD74 |
| Cytosolic DNA-sensing pathway | MB21D1,IFNA13,CCL4L2,IKBKG,IRF3,IKBKB,POLR3A,TMEM173,POLR3GL,NFKBIAB |
| RIG-I-like receptor signaling pathway | NT5C3,CASP8,OTUD5A,MAPK13,TRADD,IFNA3,IFNE,IFNA1,MAPK9,MAPK14A |
| Measles | HSPA1A,OAS2,IL1B,IRF7,IL6,TYK2,IFNA8,TNFAIP3,Ifna15,AKT1 |
| Hepatitis B | BIRC5,IFNA8,MAP2K1,DDX3X,CXCL8,STAT6,MAPK3,IFNA21,MAPK9,IFIH1 |
Protein Function
MAVS has several biochemical functions, for example, CARD domain binding,protein binding,protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAVS itself. We selected most functions MAVS had, and list some proteins which have the same functions with MAVS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein kinase binding | SQSTM1,MAP2K3,SMAD1,SPRY2,CYLD,TRIB3,ADCY6,CCNL1B,NME2,BCL2L1 |
| signal transducer activity | ATP2C1,ECM1,IL10RA,APOL3,RHOC,MC5RB,ADORA2AA,CXXC5,CC2D1A,C18orf32 |
| CARD domain binding | RIPK2,CARD11,CARD14,CARD9,NOD1,C9orf89 |
| protein binding | MAGEF1,UBE2F,C19orf10,PLAU,OGFR,KIAA1279,NAT8B,TREML2,CDC42BPG,SH3GL3 |
Interacting Protein
MAVS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAVS here. Most of them are supplied by our site. Hope this information will be useful for your research of MAVS.
DDX58;IKBKE;TMEM173
Resources
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References
- Zeng, M; Hu, ZP; et al. MAVS, cGAS, and endogenous retroviruses in T-independent B cell responses. SCIENCE 346:1486-1492(2014).
- Heim, MH; Thimme, R; et al. Innate and adaptive immune responses in HCV infections. JOURNAL OF HEPATOLOGY 61:S14-S25(2014).
