Recombinant Mouse Mapre1 Protein, Myc/DDK-tagged

• Cat.No.: Mapre1-3951M
• Product Overview: Purified recombinant protein of mouse full-length microtubule-associated protein, RP/EB family, member 1 (Mapre1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules. Acts as a regulator of autophagosome transport via interaction with CAMSAP2. May play a role in cell migration
• Molecular Mass: 30 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Mapre1 microtubule-associated protein, RP/EB family, member 1 [ Mus musculus (house mouse) ]
• Official Symbol: Mapre1
• Synonyms: MAPRE1; microtubule-associated protein, RP/EB family, member 1; microtubule-associated protein RP/EB family member 1; end-binding protein 1; APC-binding protein EB1; adenomatosis polyposis coli binding protein Eb1; Eb1; BIM1p; AI462499; AI504412; AW260097; D2Ertd459e; 5530600P05Rik
• Gene ID: 13589
• mRNA Refseq: NM_007896
• Protein Refseq: NP_031922
• UniProt ID: Q61166