Recombinant Mouse Mapk8ip1 Protein, Myc/DDK-tagged

• Cat.No.: Mapk8ip1-3946M
• Product Overview: Purified recombinant protein of mouse full-length mitogen-activated protein kinase 8 interacting protein 1 (Mapk8ip1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and thus inhibiting the JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response. Acts as a scaffold protein that coordinates with SH3RF1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the activation of MAPK8/JNK1 and differentiation of CD8+ T-cells.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 77.3 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 [ Mus musculus (house mouse) ]
• Official Symbol: Mapk8ip1
• Synonyms: IB1; Jip1; Skip; JIP-1; Prkm8ip; mjip-2a
• Gene ID: 19099
• mRNA Refseq: NM_011162
• Protein Refseq: NP_035292
• UniProt ID: Q9WVI9