Recombinant Mouse Maml1 Protein, MYC/DDK-tagged

• Cat.No.: Maml1-238M
• Product Overview: Purified recombinant protein of full-length mouse mastermind like transcriptional coactivator 1 (Maml1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 108.2 kDa
• Purity: >80%, as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 ug/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Maml1 mastermind like transcriptional coactivator 1 [ Mus musculus (house mouse) ]
• Official Symbol: Maml1
• Synonyms: Maml1; mastermind like transcriptional coactivator 1; Mam1; Mam-1; AI644666; AW743257; mKIAA0200; D930008C07Rik; mastermind-like protein 1; maml1; mastermind like 1
• Gene ID: 103806
• mRNA Refseq: NM_175334
• Protein Refseq: NP_780543
• UniProt ID: Q6T264