MAML1

  • Official Full Name

    mastermind-like 1 (Drosophila)

  • Overview

    This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway. [provided by RefSeq, Jul 2008]

  • Synonyms

    MAML1;mastermind-like 1 (Drosophila);Mam1;Mam-1;mastermind-like protein 1;mastermind homolog

Recombinant Proteins

  • Mouse
  • Human
  • Mammalian Cell
  • Mammalian cells
  • HEK293
  • HEK293T
  • His
  • Flag
  • His&Fc&Avi
  • Myc&DDK

    Involved Pathway

    MAML1 involved in several pathways and played different roles in them. We selected most pathways MAML1 participated on our site, such as Notch signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAML1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Notch signaling pathway MYCBP,DVL3A,DNER,DLL3,DLK1,DTX2,MAML2,PTCRA,HER15.1,LFNG

    Protein Function

    MAML1 has several biochemical functions, for example, peptide antigen binding,protein kinase binding,transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAML1 itself. We selected most functions MAML1 had, and list some proteins which have the same functions with MAML1. You can find most of the proteins on our site.

    Function Related Protein
    protein kinase binding FBXW5,SUFU,JIP1,PARN,SHC1,PGAM1,CDKN2A,FBXO5,MAP2K6,PEBP1
    transcription coactivator activity MYOD1,MED12,CCAR1,MED20,SOX17,NCOA2,PARK7,PSMC3,PQBP1,ING4
    peptide antigen binding HLA-G,HLA-DPB1,HLA-F,TUBB3,HLA-DRB1,MHC1UJA,TAPBP,MHC1ZFA,MHC1UIA,BF2

    Interacting Protein

    MAML1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAML1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAML1.

    Notch1

    MAML1 Related Signal Pathway

    Resources

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