Recombinant Mouse Lrrc32 Protein, Myc/DDK-tagged

• Cat.No.: Lrrc32-3829M
• Product Overview: Purified recombinant protein of mouse full-length leucine rich repeat containing 32 (Lrrc32), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: Myc&DDK
• Description: Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta. Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3).
• Molecular Mass: 72.9 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Lrrc32 leucine rich repeat containing 32 [ Mus musculus (house mouse) ]
• Official Symbol: Lrrc32
• Synonyms: LRRC32; leucine rich repeat containing 32; glycoprotein A repetitions predominant; Garp; AI426318; EG434215; D11S833Eh; D7H11S833E
• Gene ID: 434215
• mRNA Refseq: NM_001113379
• Protein Refseq: NP_001106850
• UniProt ID: G3XA59