Recombinant Mouse Lmnb2 Protein, MYC/DDK-tagged

• Cat.No.: Lmnb2-1326M
• Product Overview: Purified recombinant protein of full-length mouse lamin B2 (Lmnb2), with C-terminal MYC/DDK tag, was expressed in HEK293T cells.

Specification

• Description: This gene encodes a protein component of the nuclear lamina, which provides a structural framework for the nuclear envelope. Defects in this gene were found to cause abnormalities in the shape of neurons. This locus represents one of two B-type lamin genes that may be partially, but not entirely, functionally redundant in neuronal development. Loss of both B-type lamin genes in keratinocytes results in ichthyosis and a skin barrier defect leading to dehydration. Alternative transcriptional initiation and splicing results in multiple transcript variants and protein isoforms, including an isoform with a shorter N-terminal rod domain that may function in nuclear envelope remodeling during spermatogenesis. A related pseudogene is found on chromosome 5.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 67.3 kDa
• Purity: >80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 µg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Lmnb2 lamin B2 [ Mus musculus (house mouse) ]
• Official Symbol: Lmnb2
• Synonyms: Lmnb2; lamin B2; lamin-B2; lamin B3
• Gene ID: 16907
• mRNA Refseq: NM_010722
• Protein Refseq: NP_034852
• UniProt ID: P21619