Recombinant Mouse Jmy Protein, Myc/DDK-tagged
Cat.No. : | Jmy-3633M |
Product Overview : | Purified recombinant protein of mouse full-length junction-mediating and regulatory protein (Jmy), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
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Species : | Mouse |
Source : | HEK293 |
Tag : | DDK&Myc |
Description : | Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location. |
Molecular Mass : | 110.6 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name | Jmy junction-mediating and regulatory protein [ Mus musculus (house mouse) ] |
Official Symbol | Jmy |
Synonyms | JMY; junction-mediating and regulatory protein; junction-mediating and -regulatory protein; p300 transcriptional cofactor JMY |
Gene ID | 57748 |
mRNA Refseq | NM_021310 |
Protein Refseq | NP_067285 |
UniProt ID | Q9QXM1 |
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Jmy-3633M | Recombinant Mouse Jmy Protein, Myc/DDK-tagged | +Inquiry |
Not For Human Consumption!
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