Recombinant Mouse Interleukin 18 Binding Protein

• Cat.No.: IL18bp-1762M

Specification

• Species: Mouse
• Source: Mammalian Cells
• Tag: Non
• Description: Mouse IL-18BP is a circulating glycoprotein, which functions as an IL-18 antagonist by binding to IL-18 with high affinity and neutralizing its biological activity. IL-18BP has no amino acid sequence homology to IL-18 or IL-1 receptors. The gene for human IL-18BP encodes at least four isoforms by alternative splicing. The IL-18BP isoforms A and C each contain one immunoglobulin (Ig)-like C2-type domain while isoforms B and D lack the complete Ig domain. The complete Ig domain has been shown to be essential for IL-18BPs binding and neutralizing properties. Several poxviruses have been shown to encode proteins with sequence similarity to human and mouse IL-18BPs that also bind and inhibit IL-18 bioactivities. This could lead to viral modulation of host immune responses.
• Molecular Weight: The predicted molecular weight of Recombinant Mouse IL-18 BPd is Mr 44.5 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 60-70 kDa.
• State Of Matter: Lyophilized.
• Purity: >90% by SDS Page and analyzed by silver stain.
• Endotoxin: <1.0 EU/µg as determined by the LAL method.
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°Cto -70°C. After aseptic reconstitution, this protein may be stored at 2°Cto 8°Cfor one month or at -20°Cto -70°Cin a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Gene Information

• Gene Name: IL18bp interleukin 18 binding protein [ Mus musculus ]
• Synonyms: Il18bp; interleukin 18 binding protein; IL-18BP; Igifbp; MC54L; interferon gamma inducing factor binding protein; IL18BPa; OTTHUMP00000179141; OTTHUMP00000179143; Tadekinig-alfa; tadekinig-alfa;MC51L-53L-54L homolog gene product; interleukin18 binding protein
• Gene ID: 16068
• mRNA Refseq: NM_010531
• Protein Refseq: NP_034661
• UniProt ID: Q9Z0M9
• Chromosome Location: 7 F1