Recombinant Mouse Interleukin 1 Receptor-like 1, Fc-tagged

• Cat.No.: Il1rl1-1752M
• Product Overview: Recombinant Mouse Il1rl1 encoding the extracellular domain (amino acid residues Met 1 - Ser 342) was fused to the Fc region of human IgG1 via a polypeptide linker, inserted into a suitable baculovirus expression vector and expressed inSf21 cells.

Specification

• Species: Mouse
• Source: Sf21 Cells
• Tag: Fc
• Protein Length: 1-342 a.a.
• Description: ST2 belongs to the immunoglobulin superfamily and bears significant amino acid identity (~25%) to the extracellular portion of both type I and type II interleukin 1 receptors (IL-1R). Some of the intracellular residues that are required for signal transduction through the IL-1R and are conserved in the Drosophila Toll protein are also found in the membrane form of ST2. Furthermore, the gene for ST2 was mapped to mouse chromosome 1 closely linked to the il-1r locus containing both type I and type II receptor genes in support of their common ancestry.
• Molecular Weight: The predicted molecular weight of Recombinant Mouse IL-1 R4 is Mr 63 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 73 kDa.
• State Of Matter: Lyophilized.
• Purity: >95% by SDS Page and analyzed by silver stain.
• Endotoxin: <0.1 EU/µg as determined by the LAL method.
• Biological Activity: The biological activity of Mouse IL-1 R4 was determined by its ability to bind rmIL-33 in a functional ELISA type binding assay. The estimated KD is < 50 nM.
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°Cto -70°C. After aseptic reconstitution, this protein may be stored at 2°Cto 8°Cfor one month or at -20°Cto -70°Cin a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Gene Information

• Gene Name: Il1rl1 interleukin 1 receptor-like 1 [ Mus musculus ]
• Synonyms: Il1rl1; interleukin 1 receptor-like 1; T1; St2; DER4; Ly84; ST2L; Fit-1; T1/ST2; St2-rs1; T1; lymphocyte antigen 84; ST2; T1 gene
• Gene ID: 17082
• mRNA Refseq: NM_001025602
• Protein Refseq: NP_001020773
• UniProt ID: P14719
• Chromosome Location: 1 B; 1 20.0 cM
• Function: interleukin-1 receptor activity; interleukin-33 binding; interleukin-33 receptor activity; protein binding; receptor activity; transmembrane receptor activity