Recombinant Mouse Il17a, His-tagged

Description :	Interleukin-17 (also known as CTLA-8) is a T cell expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpesvirus Saimiri. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. An IL-17 specific mouse cell surface receptor (IL-17R) has been cloned. While the expression of IL-17 mRNA is restricted to activated alphabetaTCR+CD4-CD8-T cells, the expression of mIL-17R mRNA has been detected in virtually all cells and tissues tested. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6 and IL-8 production in fibroblasts; the enhancement of surface expression of ICAM-1 in fibroblasts; activation of NF-kappaB and costimulation of T cell proliferation.
Source :	E. coli
Species :	Mouse
Tag :	His
Form :	Lyophilized from 0.2μm-filtered solution in PBS.
Purity :	≥95% (SDS-PAGE)
Stability :	Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Storage :	Short Term Storage: +4°C; Long Term Storage: -20°C. Avoid freeze/thaw cycles.
Protein length :	22-158 a.a.

Gene Name	Il17a interleukin 17A [ Mus musculus ]
Official Symbol	Il17a
Synonyms	IL17A; interleukin 17A; interleukin-17A; cytotoxic T-lymphocyte-associated antigen 8; Il17; Ctla8; IL-17; Ctla-8; IL-17A;
Gene ID	16171
mRNA Refseq	NM_010552
Protein Refseq	NP_034682
Pathway	Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Rheumatoid arthritis, organism-specific biosystem; Rheumatoid arthritis, conserved biosystem;
Function	cytokine activity;