Recombinant Mouse Ift57 Protein, Myc/DDK-tagged

• Cat.No.: Ift57-3487M
• Product Overview: Purified recombinant protein of mouse full-length intraflagellar transport 57 (Ift57), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: Myc&DDK
• Description: Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.
• Molecular Mass: 48.8 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Ift57 intraflagellar transport 57 [ Mus musculus (house mouse) ]
• Official Symbol: Ift57
• Synonyms: IFT57; intraflagellar transport 57 homolog (Chlamydomonas); intraflagellar transport protein 57 homolog; HIP1-interacting protein; estrogen-related receptor beta like 1; Vestrogen-related receptor beta like 1; huntingtin-interacting protein-1 protein interactor; Hippi; MHS4R2; Esrrbl1; 4833420A15Rik
• Gene ID: 73916
• mRNA Refseq: NM_028680
• Protein Refseq: NP_082956
• UniProt ID: Q8BXG3