Recombinant Mouse Ifnl3, His and MBP-tagged

• Cat.No.: Ifnl3-19M
• Product Overview: Recombinant mouse IL28B/IFN lambda has the matured 174 aa at its C terminal, his tag and MBP tag at the N terminal. It is expressed and purified from an E.coli system.

Specification

• Species: Mouse
• Source: E.coli
• Tag: His&MBP
• Description: IL28B/IFN-lambda belongs to type III interferons that are class II cytokine receptor ligands. Expression of these cytokines can be induced by viral infection, such as influenza A. Lambda interferon renders epithelial cells of the respiratory and gastrointestinal tracts resistant to viral infections. Beside antiviral activity, mouse IFN-lambda also exhibit antitumor activity against B16 melanoma.
• Molecular Mass: 63.3 kD.
• Purity: Greater than 90% as determined by SDS-PAGE.
• Storage: Stored at -70°C before use. Avoid repeated freeze thaw cycles.
• Concentration: 0.5 mg/ml
• Storage Buffer: 20 mM Tris-Cl (pH 8.0), 20% Glycerol, 100 mM KCl, 1 mM DTT and 0.2 mM EDTA.

Gene Information

• Gene Name: Ifnl3 interferon lambda 3 [ Mus musculus (house mouse) ]
• Official Symbol: Ifnl3
• Synonyms: Ifnl3; interferon lambda 3; Il28; IFL-1; Il28b; IL-28B; INF-alpha; INF-lambda;interferon alpha; IFN-lambda-3; interferon lambda-3
• Gene ID: 338374
• mRNA Refseq: NM_177396
• Protein Refseq: NP_068513
• Pathway: Bile secretion, organism-specific biosystem; Bile secretion, conserved biosystem; Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem; Nuclear Receptor transcription pathway, organism-specific biosystem; Nuclear receptors in lipid metabolism and toxicity, organism-specific biosystem
• Function: DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding; RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription; bile acid binding; Contributes_to double-stranded DNA binding; metal ion binding; peptide binding; receptor activity; retinoid X receptor binding; sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding transcription factor activity; sequence-specific distal enhancer binding RNA polymerase II transcription factor activity; steroid hormone receptor activity; thyroid hormone receptor activity; zinc ion binding