Recombinant Mouse Hsf2bp Protein, Myc/DDK-tagged

• Cat.No.: Hsf2bp-3447M
• Product Overview: Purified recombinant protein of mouse full-length heat shock transcription factor 2 binding protein (Hsf2bp), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Meiotic recombination factor component of recombination bridges involved in meiotic double-strand break repair. Modulates the localization of recombinases DMC1:RAD51 to meiotic double-strand berak (DSB) sites through the interaction with BRCA2 and its recruitment during meiotic recombination. Indispensable for the DSB repair, homologous synapsis, and crossover formation that are needed for progression past metaphase I, is essential for spermatogenesis and male fertility. Required for proper recombinase recruitment in female meiosis. Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm. May be involved in modulating HSF2 activation in testis.
• Molecular Mass: 38 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Hsf2bp heat shock transcription factor 2 binding protein [ Mus musculus (house mouse) ]
• Official Symbol: Hsf2bp
• Synonyms: HSF2BP; heat shock transcription factor 2 binding protein; 4932437G14Rik
• Gene ID: 74377
• mRNA Refseq: NM_028902
• Protein Refseq: NP_083178
• UniProt ID: Q9D4G2