Recombinant Mouse Hormad2 Protein, Myc/DDK-tagged

• Cat.No.: Hormad2-3432M
• Product Overview: Purified recombinant protein of mouse full-length HORMA domain containing 2 (Hormad2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex body formation.
• Molecular Mass: 34.8 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Hormad2 HORMA domain containing 2 [ Mus musculus (house mouse) ]
• Official Symbol: Hormad2
• Synonyms: HORMAD2; HORMA domain containing 2; HORMA domain-containing protein 2; 4930529M09Rik; RP23-329P17.4
• Gene ID: 75828
• mRNA Refseq: NM_029458
• Protein Refseq: NP_083734
• UniProt ID: Q5SQP1