Recombinant Mouse Hopx Protein, Myc/DDK-tagged

• Cat.No.: Hopx-3431M
• Product Overview: Purified recombinant protein of mouse full-length HOP homeobox (Hopx), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding.
• Molecular Mass: 8.3 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Hopx HOP homeobox [ Mus musculus (house mouse) ]
• Official Symbol: Hopx
• Synonyms: HOPX; HOP homeobox; homeodomain-only protein; mOB1; odd homeobox 1; homeobox only domain; homeobox-only protein; odd homeobox protein 1; homeodomain only protein; Hod; Hop; Ob1; Obl; Hdop; Toto; Cameo; AI848177; AW490897; 1110018K11Rik; 1200015P04Rik; 2300002F06Rik
• Gene ID: 74318
• mRNA Refseq: NM_001159901
• Protein Refseq: NP_001153373
• UniProt ID: Q8R1H0