Recombinant Mouse Hook3 Protein, Myc/DDK-tagged

• Cat.No.: Hook3-3430M
• Product Overview: Purified recombinant protein of mouse full-length hook microtubule tethering protein 3 (Hook3), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. Serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track).
• Molecular Mass: 83.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Hook3 hook microtubule tethering protein 3 [ Mus musculus (house mouse) ]
• Official Symbol: Hook3
• Synonyms: HOOK3; hook homolog 3 (Drosophila); protein Hook homolog 3; mHK3; AI317159; 5830454D03Rik; E330005F07Rik
• Gene ID: 320191
• mRNA Refseq: NM_207659
• Protein Refseq: NP_997542
• UniProt ID: Q8BUK6